Research At CSU Suggests Stem Cell Therapy Beneficial To Cats In Chronic Kidney Failure

Chronic kidney failure, commonly known among veterinarians as chronic renal failure, is the number one cause of death in cats.   It is generally accepted that if a cat lives long enough, it is not a question of if he will develop kidney failure, but a question of when.   Many cats are genetically predisposed to chronic renal failure and will develop the disease before 10 years of age.

Chronic renal failure is a degenerative disease where there is progressive loss of functional kidney tissue.  As functional kidney tissue turns to scar tissue, the kidneys progressively experience a gradual reduction in key functions, including detoxification, concentrating urine, and regulating red blood cell production.

In the past, our only means of diagnosing chronic renal failure in cats was detection in general blood work with proportional elevations of two key kidney values in combination with unusually dilute urine seen on urinalysis.  By the time these circumstances manifested, however, 75% loss of functional tissue had already been lost.

With the advent of early screening with a blood test called SDMA and a change in interpretation of the key kidney value called creatinine (previously 2.1 was considered elevated, whereas now the American Feline Renal Society recognizes 1.6 or higher an indicator of renal disease), we are able to detect chronic renal failure well before there is substantial loss of functional tissue.

This has been very important for cats with chronic renal disease, where dietary modifications with prescription renal diets that limit phosphorous, sodium, and metabolic proteinaceous waste could be implemented to slow the degeneration and maintain quality of life.  While these dietary measures have proven invaluable for cats in active chronic renal failure, their role in slowing progression of early disease remains questionable.

While the renal diets are still an accepted strategy for slowing the progression of early chronic renal failure, new research at Colorado State University headed by Dr. Jessica Quimby suggests that stem cell therapy could play a key role in stabilizing degenerative chronic renal failure in cats.  Her research early on, however, indicates that once the functional tissue is gone, stem cell therapy will not restore the tissue and is not as powerful in turning back the clock on kidney health.  She states that her research shows the most significant benefit to stem cell therapy is with cats that are screened early and treated early to stabilize and halt the loss of kidney tissue before reaching the 75% loss threshold.

Still, the conclusions of Dr. Quimby’s research are still premature and she observes that stem cell therapy may still be quite helpful even for cats with more advanced stages of chronic renal disease.  She states, “Up until now, we’ve focused on cats with early stages of the disease with the hope of slowing disease progression.  We noticed that a few cats with worse stages in those studies were actually doing really well. We can’t ignore the possibility that stem cells could help those cats, too.”

With cutting edge technology from Tithon Animal Services that enables us to now harvest stem cells from peripheral via simple blood draw (the Colorado State study is using stem cells derived from fat which requires a minor surgical procedure for harvest) that my clinic is now utilizing there is a  subsequent dramatic reduction in cost and invasiveness for treatment.  With simple blood draw followed by simple IV infusion of the stem cells once they are processed (typically in 1-2 business days) there is really little reason not to attempt stem cell therapy in cats in early to advanced stages of chronic renal failure.

The biggest takeaway from this article with regard to stem cell therapy and chronic renal failure in cats is early screening of disease is key in optimizing treatment success.  Thus, by 8 years of age, every cat should be having at least once yearly blood and urinalysis screening for detection of disease and early intervention.

Dr. Roger Welton is a practicing veterinarian and highly regarded media personality through a number of topics and platforms.  In addition to being passionate about integrative veterinary medicine for which he is a nationally renowned expert, Dr. Welton was also an accomplished college lacrosse player and remains to this day very involved in the sport.  He is president of Maybeck Animal Hospital , runs the successful veterinary/animal health  blogs Web-DVM and Dr. Roger’s Holistic Veterinary Care, and fulfills his passion for lacrosse through his lacrosse and sport blog, The Creator’s Game.

Primary source for this article: https://source.colostate.edu/veterinarians-pursue-stem-cell-therapy-cats-severe-kidney-disease/

Recognition & Integrative Prevention & Treatment For An Often Overlooked Disease In Senior Aged Dogs

I hear it all the time when I ask how a senior aged canine patient is doing at the beginning of a well visit. The answer often goes something along the lines of  these variations:

“He is good, but doesn’t seem to hear well because he doesn’t come sometimes when I call him.”

“He is good, but doesn’t seem to hear that well because he doesn’t always greet people at the door anymore.”

“He is good but has selective hearing…he doesn’t not always come when called, but for some reason, he always hears his food dish being filled.”

…Etc.

In the majority of cases, simple hearing tests I perform as part of my routine physical examination reveal that the patient can hear just fine. What the owner perceives as lack of hearing or selective hearing is usually the early stages dementia, also known as Canine Cognitive Dysfunction. In fact, a Washington State University study determined that by age 11, 30% of dogs are showing early signs of dementia. The percentage of dogs with dementia increases with age until by age 16, 100% of dogs according to the same study have dementia.

Dementia in dogs results from age related changes in the brain that lead to reduced perfusion of the memory centers of the brain. These degenerative changes also lead to personality changes such as heightened anxiety, depression, insomnia, or even aggression. These changes can start as early as 7 years of age.

Clinical signs of dementia in dogs begins with them not always coming when called or not running to the door to greet people. They often seem to have selective hearing because they may still recognize their favorite cues like hearing the food bag open or seeing their owner getting the leash for a walk. As the most exciting things in their lives, feeding and walks stand out most prominently in their minds and those memories are often the last to go.

Eventually, dogs with progressing dementia may fail to recognize food and not eat, experience pacing and vocalize often in the evening hours. They may also go from having been very well house trained all of their lives to eliminating in the home.

If you have a senior aged dog (7 years or older), the following are integrative solutions that serve as proactive prevention and treatment of dementia:

1.) Omega-3 Fatty Acids: Omega-3 Fatty Acids derived from fish oil have potent anti-inflammatory activity in the body. As a key component to the cell membrane, omega-3 fatty acids also protect and maintain the integrity and health of cells. In the case of the brain, with the body lacking the ability to make new brain cells known as neurons (like people, dogs are born with a finite number of brain cells), this is key. Omega-3 fatty acids also help preserve the health of blood vessels, helping to maintain good blood flow to the brain and other organs.

2.) S-Adenosyl Methionine (SAM-E): SAM-E is a molecule that is formed naturally in the body. It can also be made in the laboratory. SAM-E is involved in the formation, activation, or breakdown of other chemicals in the body, including hormones, proteins, phospholipids; and certain drugs involved in the formation, activation, or breakdown of other chemicals in the body, including hormones, proteins, phospholipids, and certain drugs.

As a supplement, SAM-E is known to help improve mental performance, reduce depression and anxiety, and help in the treatment of many other diseases.

3.) Daily Walk: In addition to the benefits of exercise, taking your dog for a walk is mentally stimulating for them and helps to keep their mind stimulated and alert. Mental stimulation maintains blood circulation in the brain, playing a key role in brain health.

Items 1-3, I would implement for any dog 7 years or older. There is no adverse side effects or negative aspects these strategies. In fact, in addition to brain health, by implementing these simple strategies, you will also promote health in many other areas of the body. If your senior dog is experiencing confusion, selective hearing, and/or night pacing, in addition to 1-3, I would add treatment number 4.

4.) Selegiline: Selegiline is sold under the veterinary brand name Anipryl. Taken once daily, it increases dopamine production in the brain that increases perfusion to the memory centers of the brain. Selegiline also increases serotonin production in the brain, which reduces stress and anxiety associated with dementia.  Selegiline requires a prescription from your veterinarian.

If you have a senior age dog, now that you have read this article, be cognizant of subtle signs of dementia. Whether you see signs or not, take a proactive approach to prevention once your dog enters the realm of the senior years at age 7.

Dr. Roger Welton is a practicing veterinarian and highly regarded media personality through a number of topics and platforms.  In addition to being passionate about integrative veterinary medicine for which he is a nationally renowned expert, Dr. Welton was also an accomplished college lacrosse player and remains to this day very involved in the sport.  He is president of Maybeck Animal Hospital , runs the successful veterinary/animal health  blogs Web-DVM and Dr. Roger’s Holistic Veterinary Care, and fulfills his passion for lacrosse through his lacrosse and sport blog, The Creator’s Game.

A Daily Source Of Inspiration, Especially Today

March 14 is a special day.  It is the birth date of one of the most renowned scientists in history, Albert Einstein.  It is a date each year that falls within the dawn of longer days filled with sunlight, baby birds, and of the other beautiful aspects pf spring; a time of rejuvenation, rebirth, and better weather.  For me, the most beautiful aspect of this date is that it is my younger sister’s birthday.

Do I celebrate Leslie Welton Griffin’s birthday because she is my sibling that I love?  Of course!  She is a wonderful, giving person full of life, intelligence, and passion.  In her school years, Leslie was a popular girl but always was compelled to befriend everyone, most especially the kids that were ignored, shunned or treated poorly because they were different.  Leslie always found the beauty within those kids, celebrated and embraced what was different about them, and showed them what it means to be appreciated and loved unconditionally.  The adult version of her is no less magnanimous.

March 14 now means even more to the Welton family.  At age 34, after nearly 3 years of experiencing strange symptoms for which multiple doctors had no answer for, she was diagnosed with a malignant tumor in one of her lungs.  This led to an invasive surgery to remove it and save her life.

This is quite a curve ball for a person to be thrown at such a young age.  However, rather than despair over the card she was dealt, Leslie emerged full of gratitude and inspiration to not only lead a healthy and natural life style that prevents cancer, but spread her vision beyond just physical health and promote healthy mind and spirit through her blog, her line of natural products, dietary and nutritional recommendations, and positive energy.  She is driven to help others prevent and avoid what she went through.  She calls her life philosophy of living life free in mind, body, and spirit, The Free Life Recipe.  You can visit her blog at the link below:

http://www.freeliferecipe.com/

An avid animal lover, in the not so far off future, Leslie will be expanding her line of natural products into the pet world, so stay tuned for great things to come!  Happy birthday baby sister!

Dr. Roger Welton is a practicing veterinarian and highly regarded media personality through a number of topics and platforms.  In addition to being passionate about integrative veterinary medicine for which he is a nationally renowned expert, Dr. Welton was also an accomplished college lacrosse player and remains to this day very involved in the sport.  He is president of Maybeck Animal Hospital , runs the successful veterinary/animal health  blogs Web-DVM and Dr. Roger’s Holistic Veterinary Care, and fulfills his passion for lacrosse through his lacrosse and sport blog, The Creator’s Game.

Exciting Cutting Edge Stem Cell Therapy Advances In Veterinary Regenerative Medicine

Regenerative veterinary medicine refers to the repair of tissues by using the body’s own intrinsic healing mechanisms.  We activate the body’s cellular, neurological, and blood born healing capacities with side effect free therapies like Class IV therapy laser and acupuncture and the results have been remarkable.  With increasing momentum of stem cell and platelet rich plasma treatment (PRP), we are now taking regenerative medicine to another level.

Stem cells are progenitor cells that can differentiate into any tissue cell type.  By harvesting the patients’ own stem cells, activating them, and injecting them into injured areas, we are able to repair tissues at the cellular level.  In the past, the harvesting of stem cells has required a minor surgical procedure with general anesthesia where fat from the body is sampled and sent off to a lab to have the stem cells extracted and processed into an injectable media.  Since injection of joints, one of the most common uses of stem cell therapy in veterinary medicine, almost always requires sedation, the costs and client perceived invasiveness associated with anesthesia, minor surgery followed by sedation, clients have often been reluctant to consider it for their pet. As a result, although most veterinarians are strong advocates of this branch of medicine, to date we have found it a tough sell for pet owners.

With new technology from PrimoStem, the general anesthesia and surgical portion of stem cell therapy has been taken out of the process.  Their new technology does not require tissue harvest for collection of stem cells, but instead is able to extract and activate stem cells from a simple blood draw.  The blood is sent off to their lab and within 2 business days arrives to the clinic ready for injection.  Thus, your pet can now enjoy the benefits of stem cell therapy for any number of conditions with a simple blood draw, gentle sedation, and injection into damaged areas of the body, all within a 3 day turn around and two outpatient visits.

Stems cell solutions are directly injected into damaged joints and acupuncture points to seek out, differentiate into the given tissue cell type, and repair it. In addition to direct injection, the patient is given an additional intravenous bolus of stem cells to provide systemic regenerative benefits throughout the entire body.

The applications of this type of treatment is poised to go far beyond orthopedic repair.  As I write this article, there are currently studies in process to assess the benefits of this treatment for chronic degenerative disease such as kidney failure, cirrhosis of the liver, and several degenerative neurological conditions that traditional veterinary medicine previously had no answer for.  Conclusions are still pending as the data continues to be collected, but initial results seem very promising.

Dr. Roger Welton is a practicing veterinarian and highly regarded media personality through a number of topics and platforms.  In addition to being passionate about integrative veterinary medicine for which he is a nationally renowned expert, Dr. Welton was also an accomplished college lacrosse player and remains to this day very involved in the sport.  He is president of Maybeck Animal Hospital , runs the successful veterinary/animal health  blogs Web-DVM and Dr. Roger’s Holistic Veterinary Care, and fulfills his passion for lacrosse through his lacrosse and sport blog, The Creator’s Game.

A Simple Feeding Strategy That May Significantly Reduce Cancer In Dogs

In my last post, I discussed the dramatic rise in cancer in pets in past 10 years, as well as some of the proposed reasons for it.  In this post, I would like to focus on one particular study that provides a potentially profound yet simple way that we may decrease the incidence of cancer in dogs.  If you have not yet read my last post, here it is:

Why Is There So Much Cancer In Pets?

Per my last post, the processing of food and the subsequent creation of glycotoxins in processed diets that have an oxidant effect on the body.  Oxidants create oxidative stress to tissues and serve to some degree to negate dietary antioxidants that are known to boost the immune system and prevent cancer.

However, home prepared diets are not necessarily the solution to this issue, as it can be very challenging to properly nutritionally balance a home prepared diet, leading to nutrient deficiencies that can lead to a host of disease, including cancer.  Dr. Rob Silver, a cutting edge integrative veterinary practitioner and researcher at Colorado State University cited a recent study that may solve this dietary conundrum.

Scottish Terriers as a breed are statistically more prone to urinary bladder cancer (called transitional cell carcinoma – called TCC).  As such, they were chosen for a study that compared three test groups:

1.) Dogs fed only a reputable kibble diet.

2.) Dogs fed a reputable kibble diet with green leafy vegetables added to it.

3.) Home prepared diets with no kibble.

The study was quite revealing.  The Scottish Terriers in the second group that were fed kibble with the addition of green leafy vegetables were 70% – 90% less likely to develop TCC in comparison to groups 1 and 3 that were fed pure kibble and home prepared diets with no kibble, respectively.

The conclusions of this study are very clear from my view:

  • There are additional factors outside of genetic predisposition that determine whether or not a dog will develop cancer, as clearly genetic predilection can be affected one way or another by other factors, in this case nutrition.
  • Home prepared diets, likely due to the challenges of balancing them from a nutrient perspective, are not necessarily the answer to dietary cancer prevention in dogs.
  • Feeding kibble provides nutrient balance, but a neutralizing effect of glycotoxins by the addition of antioxidant rich green leafy vegetables may profoundly prevent cancer, providing us the ability to proverbially have our cake and eat it too.

Regarding green vegetables that are among the highest in antioxidants, two optimal choices for addition to kibble diets are spinach, kale and broccoli.  You would generally want to include as close to 20% of total feeding volume represented as vegetables as the dog will still readily eat.

Dr. Roger Welton is a practicing veterinarian and highly regarded media personality through a number of topics and platforms.  In addition to being passionate about integrative veterinary medicine for which he is a nationally renowned expert, Dr. Welton was also an accomplished college lacrosse player and remains to this day very involved in the sport.  He is president of Maybeck Animal Hospital , runs the successful veterinary/animal health  blogs Web-DVM and Dr. Roger’s Holistic Veterinary Care, and fulfills his passion for lacrosse through his lacrosse and sport blog, The Creator’s Game.